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Article

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

Oncogene - 4 Feb 1999

Bardelli A, Basile M L, Audero E, Giordano S, Wennström S, Ménard S, Comoglio P M, Ponzetto C

Abstract excerpt

The Met tyrosine kinase - the HGF receptor - induces cell transformation and metastasis when constitutively activated. Met signaling is mediated by phosphorylation of two carboxy-terminal tyrosines which act as docking sites for a number of SH2-containing molecules. These include Grb2 and p85 which couple the receptor, respectively, with Ras and PI 3-kinase. We previously showed that a Met mutant designed to...

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Source

Identifiers

PMID: 10022119
DOI: 10.1038/sj.onc.1202607

Genes

HGF
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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