Article
Regulation of the wild-type and Y1235D mutant Met kinase activation.
Biochemistry - 1 Nov 2005
Cristiani Cinzia, Rusconi Luisa, Perego Rita, Schiering Nikolaus, Kalisz Henryk M, Knapp Stefan, Isacchi Antonella
Abstract excerpt
Met receptor tyrosine kinase plays a crucial role in the regulation of a large number of cellular processes and, when deregulated by overexpression or mutations, leads to tumor growth and invasion. The Y1235D mutation identified in metastases was shown to induce constitutive activation and a motile-invasive phenotype on transduced carcinoma cells. Wild-type Met activation requires phosphorylation of both Y1234...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.