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Molecular markers in dysplasia of the larynx: expression of cyclin-dependent kinase inhibitors p21, p27 and p53 tumour suppressor gene in predicting cancer risk.

Clinical otolaryngology and allied sciences - 1 Dec 2004

Jeannon J-P, Soames J V, Aston V, Stafford F W, Wilson J A

Abstract excerpt

Premalignant conditions affect the larynx. Dysplasia can progress in severity resulting in cancer depending on many clinical, pathological and molecular factors. The purpose of this study was to examine the expression of the p21 and p27 cyclin-dependent kinase inhibitors and p53 tumour suppressor gene in dysplasia of the larynx. A total of 114 cases of untreated dysplasia were selected from the archives of the...

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PMID: 15533163
DOI: 10.1111/j.1365-2273.2004.00859.x

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