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Article

The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase.

Endocrinology - 1 Dec 1997

Sun B C, Harney J W, Berry M J, Larsen P R

Abstract excerpt

Type 1 iodothyronine deiodinase (deiodinase 1) is a selenoenzyme that converts the prohormone T4 to the active thyroid hormone T3 by outer ring deiodination or to the inactive metabolite rT3 by inner ring deiodination. Although selenocysteine has been demonstrated to be essential for the biochemical profile of deiodinase 1, the role of a highly conserved, active site cysteine (C124 in rat deiodinase 1) has not...

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Identifiers

PMID: 9389531
DOI: 10.1210/endo.138.12.5623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase.PMID 9389531Read ↗

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