Article
The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase.
Endocrinology - 1 Dec 1997
Sun B C, Harney J W, Berry M J, Larsen P R
Abstract excerpt
Type 1 iodothyronine deiodinase (deiodinase 1) is a selenoenzyme that converts the prohormone T4 to the active thyroid hormone T3 by outer ring deiodination or to the inactive metabolite rT3 by inner ring deiodination. Although selenocysteine has been demonstrated to be essential for the biochemi...
Topics
- Amino Acid Sequence
- Animals
- Catalysis
- Conserved Sequence
- Cysteine
- Dithiothreitol
- Glutathione
- Iodide Peroxidase
- Iodine
- Isoenzymes
- Molecular Sequence Data
- Mutation
- Osmolar Concentration
- Propylthiouracil
- Rats