Conserved cysteines in the type 1 deiodinase selenoprotein are not essential for catalytic activity.

doi:10.1074/jbc.273.39.25230

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Article

Conserved cysteines in the type 1 deiodinase selenoprotein are not essential for catalytic activity.

The Journal of biological chemistry - 25 Sept 1998

Croteau W, Bodwell J E, Richardson J M, St Germain D L

Abstract excerpt

The iodothyronine deiodinases are a family of oxidoreductases that catalyze the removal of iodide from thyroid hormones. Each of the three isoforms contain selenocysteine at its active site and several cysteine residues that may be important for catalytic activity. Of particular interest in the t...

Topics

Animals
COS Cells
Catalysis
Cysteine
Iodide Peroxidase
Kinetics
Mutation
Proteins
Rats
Selenoproteins

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