Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation.

doi:10.1210/endo.131.4.1396330

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Article

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation.

Endocrinology - 1 Oct 1992

Berry M J, Maia A L, Kieffer J D, Harney J W, Larsen P R

Abstract excerpt

Type I iodothyronine 5' deiodinase (5'DI) contains selenocysteine, encoded by a UGA codon, and this amino acid is essential for maximum catalytic efficiency in this enzyme. We recently showed that translation of UGA as selenocysteine in this protein requires a specific sequence of about 250 nucle...

Topics

Catalysis
Cell Line, Transformed
Cysteine
Half-Life
Iodide Peroxidase
Kidney
Mutation
Placenta
Protein Biosynthesis
Selenocysteine

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