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Article

Growth and Muscle Defects in Mice Lacking Adult Myosin Heavy Chain Genes

1 Dec 1997

Abstract excerpt

The three adult fast myosin heavy chains (MyHCs) constitute the vast majority of the myosin in adult skeletal musculature, and are >92% identical. We describe mice carrying null mutations in each of two predominant adult fast MyHC genes, IIb and IId/x. Both null strains exhibit growth and muscle defects, but the defects are different between the two strains and do not correlate with the abundance or distribution...

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PMID: 9382868
DOI: 10.1083/jcb.139.5.1219

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