Article
Mouse models for thin filament disease.
Advances in experimental medicine and biology - 1 Jan 2008
Nguyen Mai-Anh T, Hardeman Edna C
Abstract excerpt
Thin filament integrity is important for the ordered structure and function of skeletal muscles. Mutations within genes that encode thin filament and thin filament-associated proteins can cause muscle disruption, fiber atrophy and alter fiber type composition, leading to muscle weakness. Analyses of patient biopsy samples and tissue culture systems provide rapid methods for studying disease-causing mutations....
Topics
- Animals
- Disease Models, Animal
- Humans
- Mice
- Muscle Fibers, Skeletal
- Muscle Proteins
- Muscular Diseases
- Mutation