Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period.

doi:10.1128/MCB.22.16.5887-5896.2002

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Article

Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period.

Molecular and cellular biology - 1 Aug 2002

Crawford K, Flick R, Close L, Shelly D, Paul R, Bove K, Kumar A, Lessard J

Abstract excerpt

All four of the muscle actins (skeletal, cardiac, vascular, and enteric) in higher vertebrates show distinct expression patterns and display highly conserved amino acid sequences. While it is hypothesized that each of the muscle isoactins is specifically adapted to its respective tissue and that the minor variations among them have developmental and/or physiological relevance, the exact functional and...

Topics

Actins
Animals
Animals, Newborn
Gene Targeting
Humans
Mice
Mice, Knockout
Muscle Contraction
Muscle, Skeletal
Phenotype
Protein Isoforms
Stem Cells

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Identifiers

PMID: 12138199
DOI: 10.1128/MCB.22.16.5887-5896.2002
PMCID: PMC133984

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