Article
Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2007
Wang Yingcai, Szczesna-Cordary Danuta, Craig Roger, Diaz-Perez Zoraida, Guzman Georgianna, Miller Todd, Potter James D
Abstract excerpt
In skeletal muscle, the myosin molecule contains two sets of noncovalently attached low molecular weight proteins, the regulatory (RLC) and essential (ELC) light chains. To assess the functional and developmental significance of the fast skeletal isoform of the RLC (RLC-f), the murine fast skeletal RLC gene (Mylpf) was disrupted by homologous recombination. Heterozygotes containing an intronic neo cassette...
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