Article
Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy.
American journal of physiology. Cell physiology - 1 Mar 2001
Allen D L, Harrison B C, Sartorius C, Byrnes W C, Leinwand L A
Abstract excerpt
The fast skeletal IIb gene is the source of most myosin heavy chain (MyHC) in adult mouse skeletal muscle. We have examined the effects of a null mutation in the IIb MyHC gene on the growth and morphology of mouse skeletal muscle. Loss in muscle mass of several head and hindlimb muscles correlated with amounts of IIb MyHC expressed in that muscle in wild types. Decreased mass was accompanied by decreases in mean...
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