Article
Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jan 2002
Harrison B C, Bell M L, Allen D L, Byrnes W C, Leinwand L A
Abstract excerpt
10.1152/ japplphysiol.00832.2001.-To examine the effects of gene inactivation on the plasticity of skeletal muscle, mice null for a specific myosin heavy chain (MHC) isoform were subjected to a voluntary wheel-running paradigm. Despite reduced running performance compared with nontransgenic C57BL/6 mice (NTG), both MHC IIb and MHC IId/x null animals exhibited increased muscle fiber size and muscle oxidative...
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