Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype.

Molecular pharmacology - 1 Oct 1997

Parsels L A, Zellars R C, Loney T L, Parsels J D, Clarke M F, Merchant A K, Lawrence T S, Maybaum J

Abstract excerpt

We have examined the effects of conditionally expressing wild-type p53 activity in HT29 cells on DNA damage and cytotoxicity caused by exposure to fluorodeoxyuridine (FdUrd). Expression of wild-type p53 phenotype for 24 hr before FdUrd treatment provided HT29 cells with virtually complete protection from cytotoxicity caused by this drug. In addition, wild-type p53 expression also prevented FdUrd-induced DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to DNA Damage

Share to Electrophoresis, Gel, Pulsed-Field

Share to Genes, p53

Share to Phenotype

Source

Identifiers

PMID: 9380022
DOI: 10.1124/mol.52.4.600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype.PMID 9380022Read ↗

Disruption of p53 in human cancer cells alters the responses to therapeutic agentsSemantic proximity Read ↗

Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis.Semantic proximity Read ↗

Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines.Semantic proximity Read ↗

Cellular Response to Chemoradiotherapy, Radiotherapy and Chemotherapy in Two Colorectal Cancer Cell LinesSemantic proximity Read ↗

Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function.Semantic proximity Read ↗

Wild-type p53 protein potentiates phototoxicity of 2-BA-2-DMHA in HT29 cells expressing endogenous mutant p53.Semantic proximity Read ↗

Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.Semantic proximity Read ↗

Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice.Semantic proximity Read ↗

A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2'-deoxyuridine in mammalian and bacterial cells.Semantic proximity Read ↗

Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.Semantic proximity Read ↗

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.Semantic proximity Read ↗

Schedule-dependent cytotoxicity of SN-38 in p53 wild-type and mutant colon adenocarcinoma cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.