Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines.

doi:10.1016/s1011-1344(97)00130-9

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Article

Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines.

Journal of photochemistry and photobiology. B, Biology - 1 Feb 1998

Fisher A M, Rucker N, Wong S, Gomer C J

Abstract excerpt

Tumor sensitivity to cancer therapies may be modulated by the p53 status of the malignant cells. Generally, tumors retaining wild-type p53 are more sensitive to radiotherapy and some chemotherapeutic agents than are tumors with either a mutated or deleted p53 phenotype. The role of p53 in the res...

Topics

Colonic Neoplasms
Humans
Mutation
Photochemotherapy
Radiation Tolerance
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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