Article
Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines.
Journal of photochemistry and photobiology. B, Biology - 1 Feb 1998
Fisher A M, Rucker N, Wong S, Gomer C J
Abstract excerpt
Tumor sensitivity to cancer therapies may be modulated by the p53 status of the malignant cells. Generally, tumors retaining wild-type p53 are more sensitive to radiotherapy and some chemotherapeutic agents than are tumors with either a mutated or deleted p53 phenotype. The role of p53 in the responsiveness to PDT as a cancer treatment is clinically unknown. In the current study, we evaluated the photosensitivity...
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