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Article

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 Aug 1999

Abstract excerpt

We have examined the effects of commonly used chemotherapeutic agents on human colon cancer cell lines in which the p53 pathway has been specifically disrupted by targeted homologous recombination. We found that p53 had profound effects on drug responses, and these effects varied dramatically depending on the drug. The p53-deficient cells were sensitized to the effects of DNA-damaging agents as a result of the...

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PMID: 10430607
DOI: 10.1172/jci6863

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