Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis.

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Article

Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis.

International journal of oncology - 1 Apr 2004

Barberi-Heyob Muriel, Védrine Pierre-Olivier, Merlin Jean-Louis, Millon Régine, Abecassis Joseph, Poupon Marie-France, Guillemin François

Abstract excerpt

Photodynamic therapy (PDT) is an effective local cancer treatment that induces cytotoxicity through the intracellular generation of reactive oxygen species. It is generally thought that p53 regulates chemotherapy and radiation therapy responsiveness via apoptosis induction control. The current study investigated whether cellular sensitivity to PDT is increased when a wild-type (wt) p53 status is restored by gene...

Topics

Apoptosis
Chlorophyllides
Genes, p53
HT29 Cells
Humans
Mutation
Photochemotherapy
Porphyrins
Radiation-Sensitizing Agents
Transfection
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 15010835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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