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Article

Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice.

Cancer letters - 26 May 2001

Schumacher U, Adam E, Feldhaus S, Katoh M, Lane D P

Abstract excerpt

Absence of a functional p53 gene product can lead to increased p53 accumulation in cancer cells. In this contribution, the association between cell differentiation, chemotherapy and p53 immunoreactivity in human HT29 colon cancer cells grown in scid mice as undifferentiated cells and as mucin containing signet-ring cells was investigated. Mutated p53 was more frequently expressed in the undifferentiated tumour...

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Identifiers

PMID: 11311495
DOI: 10.1016/s0304-3835(01)00395-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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