Article
A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2'-deoxyuridine in mammalian and bacterial cells.
Molecular pharmacology - 1 Aug 1992
Barbour K W, Hoganson D K, Berger S H, Berger F G
Abstract excerpt
Structural changes in the macromolecular targets of pharmacological agents can result in alterations in the efficacy of these agents. In previous studies, we identified a variant structural form of thymidylate synthase (TS) that is associated with relative resistance to 5-fluoro-2'-deoxyuridine,...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- Cricetinae
- Cricetulus
- DNA
- Drug Resistance
- Escherichia coli
- Floxuridine
- Gene Expression
- Genes, Viral
- Genetic Variation
- Histidine
- Humans
- Lung
- Mammary Tumor Virus, Mouse
- Molecular Sequence Data