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Cellular Response to Chemoradiotherapy, Radiotherapy and Chemotherapy in Two Colorectal Cancer Cell Lines

28 Apr 2009

Abstract excerpt

The cellular response to chemoradiotherapy was investigated in cells of the HCT116 (wild-type TP53) and HT29 (mutated TP53) human colorectal cancer cell lines to better understand how the chemotherapeutic agent 5-fluorouracil (5-FU) acts as a radiosensitizer in vitro and how it contributes to the well-documented greater efficacy of chemoradiotherapy compared to radiotherapy (or chemotherapy) alone. A bolus 5-FU...

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PMID: 19580491
DOI: 10.1667/rr1524.1

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