Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

doi:10.1073/pnas.89.10.4495

Article

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

15 May 1992

Abstract excerpt

A wild-type p53 gene under control of the metallothionein MT-1 promoter was stably transfected into human colon tumor-derived cell line EB. Repeated inductions of the metallothionein wild-type p53 gene with zinc chloride results in progressive detachment of wild-type p53 cells grown on culture dishes. Examination at both the light and electron microscopic level revealed that cells expressing wild-type p53...

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