Article
Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer.
Oncogene - 14 May 1998
Huang C, Taki T, Adachi M, Konishi T, Higashiyama M, Miyake M
Abstract excerpt
This study was performed to clarify the different effects of each mutant exon of p53 as indicators of a poor prognosis in patients with non-small cell lung cancer (NSCLC). Tumor tissues of 204 patients with NSCLC were analysed; 96 tumors were stage I, 22 stage II, and 86 stage III. DNA was extrac...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Exons
- Female
- Genes, p53
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Plants, Toxic
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prognosis