Article
p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Aug 2007
Massoni Neto L M, Bianchi C P, Ab'Saber A M, Parra E R, Takagaki T, Pereira J C, Soares F A, Leite K, Capelozzi V L
Abstract excerpt
Malignancy of pulmonary large cell carcinomas (LCC) increases from classic LCC through LCC with neuroendocrine morphology (LCCNM) to large cell neuroendocrine carcinomas (LCNEC). However, the histological classification has sometimes proved to be difficult. Because the malignancy of LCC is highly dependent on proteins with functions in the cell cycle, DNA repair, and apoptosis, p53 has been targeted as a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.