Article
Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.
The Journal of biological chemistry - 28 Nov 1997
Krook A, Whitehead J P, Dobson S P, Griffiths M R, Ouwens M, Baker C, Hayward A C, Sen S K, Maassen J A, Siddle K, Tavaré J M, O'Rahilly S
Abstract excerpt
We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --> Gln and Pro-1178 --> Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis...
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