Article
Activation of glucose transport by a natural mutation in the human insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1993
Longo N, Langley S D, Griffin L D, Elsas L J
Abstract excerpt
Naturally occurring mutations in the insulin receptor gene cause heritable severe insulin resistance. These mutations usually impair insulin receptor signaling in cells cultured from affected individuals. However, fibroblasts cultured from a patient with intrauterine growth restriction and severe...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- CHO Cells
- Cell Division
- Cells, Cultured
- Cricetinae
- DNA
- Female
- Fetal Growth Retardation
- Fibroblasts
- Glucose
- Humans
- Insulin Resistance
- Kinetics
- Male
- Molecular Sequence Data