Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of glucose transport by a natural mutation in the human insulin receptor.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1993

Longo N, Langley S D, Griffin L D, Elsas L J

Abstract excerpt

Naturally occurring mutations in the insulin receptor gene cause heritable severe insulin resistance. These mutations usually impair insulin receptor signaling in cells cultured from affected individuals. However, fibroblasts cultured from a patient with intrauterine growth restriction and severe insulin resistance (leprechaun Atl-1) had normal amounts of insulin receptor protein and defective insulin binding but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Cells, Cultured

Share to Cricetinae

Share to Kinetics

Share to Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 8419945
DOI: 10.1073/pnas.90.1.60
PMCID: PMC45599

Genes

CGA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of glucose transport by a natural mutation in the human insulin receptor.PMID 8419945Read ↗

Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells.Semantic proximity Read ↗

Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.Semantic proximity Read ↗

A mutation in the insulin receptor that impairs proreceptor processing but not insulin binding.Semantic proximity Read ↗

Reduced mRNA and a nonsense mutation in the insulin-receptor gene produce heritable severe insulin resistance.Semantic proximity Read ↗

Genotype-phenotype correlation in inherited severe insulin resistance.Semantic proximity Read ↗

Molecular biology of insulin resistance.Semantic proximity Read ↗

An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.Semantic proximity Read ↗

Mutant insulin receptors in syndromes of insulin resistance.Semantic proximity Read ↗

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.Semantic proximity Read ↗

Identification and functional assessment of novel and known insulin receptor mutations in five patients with syndromes of severe insulin resistance.Semantic proximity Read ↗

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.Semantic proximity Read ↗

Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: impaired insulin-stimulated c-jun expression and thymidine incorporation despite normal receptor autophosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.