Article
Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action.
The Journal of biological chemistry - 25 Apr 1992
Cama A, Quon M J, de la Luz Sierra M, Taylor S I
Abstract excerpt
The intracellular domain of the insulin receptor possesses activity as a tyrosine-specific protein kinase. The receptor tyrosine kinase is stimulated by insulin binding to the extracellular domain of the receptor. Previously, we have identified a patient with a genetic form of insulin resistance...
Topics
- 3T3 Cells
- Animals
- DNA
- Endocytosis
- Enzyme Activation
- Female
- Heterozygote
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Isoleucine
- Methionine
- Mice
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptor, Insulin
- Transfection