Article
Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax: potential mechanisms for survival enhancing effects.
Blood - 1 Dec 1997
Ritchie A, Gotoh A, Gaddy J, Braun S E, Broxmeyer H E
Abstract excerpt
Thrombopoietin (Tpo) has proliferative and maturational effects on immature and more committed cells, respectively. We previously reported a role for Tpo as a survival factor in the factor-dependent human cell line M07e by demonstrating that Tpo suppresses apoptosis in the absence of induced prol...
Topics
- Blotting, Western
- Cell Division
- Cell Survival
- Cells, Cultured
- Humans
- Phenotype
- Promoter Regions, Genetic
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Recombinant Proteins
- Thrombopoietin
- Tumor Suppressor Protein p53
- Up-Regulation
- bcl-2-Associated X Protein