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Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2

1 Sept 1996

Abstract excerpt

Erythropoietin (Epo), the hormone that is the principal regulator of red blood cell production, interacts with high-affinity receptors on the surface of erythroid progenitor cells and maintains their survival. Epo has been shown to promote cell viability by repressing apoptosis; however, the molecular mechanism involved is unclear. In the present studies we have examined whether Epo acts as a survival factor...

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Share to Blood properties and coagulation
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Share to Erythrocyte Function and Pathophysiology

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PMID: 8781412
DOI: 10.1182/blood.v88.5.1576.1576

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