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Article

RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution.

Molecular and cellular biology - 1 Dec 1997

Li W, Swanson P, Desiderio S

Abstract excerpt

V(D)J recombination is initiated by RAG-1 and RAG-2, which introduce double-strand DNA breaks at recombination signal sequences (RSSs) of antigen receptor gene segments to produce signal ends, terminating in blunt, double-strand breaks, and coding ends, terminating in DNA hairpins. While the formation of RAG-RSS complexes has been documented, observations regarding the individual contributions of RAG-1 and RAG-2...

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Source

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Identifiers

PMID: 9372925
DOI: 10.1128/MCB.17.12.6932
PMCID: PMC232550

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Source receipt: pubmed, retrieved 7 Sept 2026.

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RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution.PMID 9372925Read ↗

Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.Semantic proximity Read ↗

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.Semantic proximity Read ↗

Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.Semantic proximity Read ↗

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins.Semantic proximity Read ↗

Requirements for DNA hairpin formation by RAG1/2.Semantic proximity Read ↗

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.Semantic proximity Read ↗

Single-molecule analysis of RAG-mediated V(D)J DNA cleavage.Semantic proximity Read ↗

Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.Semantic proximity Read ↗

Identification and characterization of a gain-of-function RAG-1 mutant.Semantic proximity Read ↗

Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.Semantic proximity Read ↗

Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Semantic proximity Read ↗

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination.Semantic proximity Read ↗

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