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Article

Requirements for DNA hairpin formation by RAG1/2.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2007

Grundy Gabrielle J, Hesse Joanne E, Gellert Martin

Abstract excerpt

The rearrangement of antigen receptor genes is initiated by double-strand breaks catalyzed by the RAG1/2 complex at the junctions of recombination signal sequences and coding segments. As with some "cut-and-paste" transposases, such as Tn5 and Hermes, a DNA hairpin is formed at one end of the break via a nicked intermediate. By using abasic DNA substrates, we show that different base positions are important for...

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Identifiers

PMID: 17307873
DOI: 10.1073/pnas.0611293104
PMCID: PMC1805602

Genes

RAG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Requirements for DNA hairpin formation by RAG1/2.PMID 17307873Read ↗

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