The TBP-TFIIA interaction in the response to acidic activators in vivo.

doi:10.1126/science.7604282

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Article

The TBP-TFIIA interaction in the response to acidic activators in vivo.

Science (New York, N.Y.) - 7 Jul 1995

Stargell L A, Struhl K

Abstract excerpt

A yeast TBP mutant (N2-1) is described here that is defective specifically in responding to acidic activators in vivo. N2-1 does not support activation by Gal4, Ace1, and Gcn4, but appears unaffected for constitutive transcription, repression by the Cyc8-Tup1 and Not complexes, and transcription by polymerase I (Pol) and Pol III. In vitro, N2-1 fails to interact with TFIIA, but it associates normally with a TATA...

Topics

Base Sequence
DNA-Binding Proteins
DNA-Directed RNA Polymerases
Fungal Proteins
Hydrogen-Ion Concentration
Immediate-Early Proteins
Molecular Sequence Data
Mutation
Nuclear Proteins
Nuclear Receptor Subfamily 4, Group A, Member 2
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

TATA Box

TATA-Box Binding Protein

Trans-Activators

Transcription Factor TFIIA

Source

Open in PubMed

Identifiers

PMID: 7604282
DOI: 10.1126/science.7604282

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7604282-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.Semantic proximity Read ↗

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