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Article

The TBP-TFIIA interaction in the response to acidic activators in vivo.

Science (New York, N.Y.) - 7 Jul 1995

Stargell L A, Struhl K

Abstract excerpt

A yeast TBP mutant (N2-1) is described here that is defective specifically in responding to acidic activators in vivo. N2-1 does not support activation by Gal4, Ace1, and Gcn4, but appears unaffected for constitutive transcription, repression by the Cyc8-Tup1 and Not complexes, and transcription by polymerase I (Pol) and Pol III. In vitro, N2-1 fails to interact with TFIIA, but it associates normally with a TATA...

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Source

Identifiers

PMID: 7604282
DOI: 10.1126/science.7604282

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The TBP-TFIIA interaction in the response to acidic activators in vivo.PMID 7604282Read ↗

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The Drosophila TATA binding protein contains a strong but masked activation domain.Semantic proximity Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

Analysis of TFIIA function In vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation.Semantic proximity Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

Interplay of TBP inhibitors in global transcriptional control.Semantic proximity Read ↗

TBP-associated factors are not generally required for transcriptional activation in yeast.Semantic proximity Read ↗

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.Semantic proximity Read ↗

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