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Article

TFIIA has activator-dependent and core promoter functions in vivo.

The Journal of biological chemistry - 28 Apr 2000

Stargell L A, Moqtaderi Z, Dorris D R, Ogg R C, Struhl K

Abstract excerpt

The physiological role of TFIIA was investigated by analyzing transcription in a yeast strain that contains a TATA-binding protein (TBP) mutant (N2-1) defective for interacting with TFIIA. In cells containing N2-1, transcription from a set of artificial his3 promoters dependent on different activators is generally reduced by a similar extent, indicating that TFIIA function is largely nonselective for activators....

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Source

Identifiers

PMID: 10777519
DOI: 10.1074/jbc.275.17.12374

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TFIIA has activator-dependent and core promoter functions in vivo.PMID 10777519Read ↗

The TBP-TFIIA interaction in the response to acidic activators in vivo.Semantic proximity Read ↗

Analysis of TFIIA function In vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation.Semantic proximity Read ↗

Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly.Semantic proximity Read ↗

Distinct classes of yeast promoters revealed by differential TAF recruitment.Semantic proximity Read ↗

Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.Semantic proximity Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

TBP-associated factors are not generally required for transcriptional activation in yeast.Semantic proximity Read ↗

Transcription activation in cells lacking TAFIIS.Semantic proximity Read ↗

Interplay of TBP inhibitors in global transcriptional control.Semantic proximity Read ↗

Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4.Semantic proximity Read ↗

Tc, an unusual promoter element required for constitutive transcription of the yeast HIS3 gene.Semantic proximity Read ↗

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