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Article

Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.

DNA repair - 1 Dec 2007

Longerich Simonne, Meira Lisiane, Shah Dharini, Samson Leona D, Storb Ursula

Abstract excerpt

Somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes require the cytosine deaminase AID, which deaminates cytosine to uracil in Ig gene DNA. Paradoxically, proteins involved normally in error-free base excision repair and mismatch repair, seem to be co-opted to facilitate SHM and CSR, by recruiting error-prone translesion polymerases to DNA sequences containing...

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Identifiers

PMID: 17681497
DOI: 10.1016/j.dnarep.2007.06.012
PMCID: PMC2196218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.PMID 17681497Read ↗

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