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Article

Probing the mutational landscape of regulators of G protein signaling proteins in cancer.

Science signaling - 4 Feb 2020

DiGiacomo Vincent, Maziarz Marcin, Luebbers Alex, Norris Jillian M, Laksono Pandu, Garcia-Marcos Mikel

Abstract excerpt

The advent of deep-sequencing techniques has revealed that mutations in G protein-coupled receptor (GPCR) signaling pathways in cancer are more prominent than was previously appreciated. An emergent theme is that cancer-associated mutations tend to cause enhanced GPCR pathway activation to favor oncogenicity. Regulators of G protein signaling (RGS) proteins are critical modulators of GPCR signaling that dampen...

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Source

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Identifiers

PMID: 32019900
DOI: 10.1126/scisignal.aax8620
PMCID: PMC7079226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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