Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.

The Journal of biological chemistry - 4 Aug 2000

Cavalli A, Druey K M, Milligan G

Abstract excerpt

Agonist-stimulated high affinity GTPase activity of fusion proteins between the alpha(2A)-adrenoreceptor and the alpha subunits of forms of the G proteins G(i1), G(i2), G(i3), and G(o1), modified to render them insensitive to the action of pertussis toxin, was measured following transient expression in COS-7 cells. Addition of a recombinant regulator of G protein signaling protein, RGS4, did not significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic alpha-Agonists
Share to GTP-Binding Protein alpha Subunits, Gi-Go

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterotrimeric GTP-Binding Proteins

Share to Proto-Oncogene Proteins

Share to Quinoxalines

Share to Receptors, Adrenergic, alpha-2

Share to RGS Proteins

Source

Identifiers

PMID: 10807934
DOI: 10.1074/jbc.M910395199

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.PMID 10807934Read ↗

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.Semantic proximity Read ↗

RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins.Semantic proximity Read ↗

Differential effects of RGS proteins on G alpha(q) and G alpha(11) activity.Semantic proximity Read ↗

Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels.Semantic proximity Read ↗

Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex.Semantic proximity Read ↗

The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling.Semantic proximity Read ↗

Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes.Semantic proximity Read ↗

Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins.Semantic proximity Read ↗

Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteinsSemantic proximity Read ↗

<i>In vitro</i> profiling of orphan G protein coupled receptor (GPCR) constitutive activitySemantic proximity Read ↗

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction.Semantic proximity Read ↗

The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.