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Article

Regulation of polymyxin resistance and adaptation to low-Mg2+ environments.

Journal of bacteriology - 1 Nov 1997

Groisman E A, Kayser J, Soncini F C

Abstract excerpt

The PmrA-PmrB two-component system of Salmonella typhimurium controls resistance to the peptide antibiotic polymyxin B and to several antimicrobial proteins from human neutrophils. Amino acid substitutions in the regulatory protein PmrA conferring resistance to polymyxin lower the overall negative charge of the lipopolysaccharide (LPS), which results in decreased bacterial binding to cationic polypeptides and...

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Identifiers

PMID: 9371451
DOI: 10.1128/jb.179.22.7040-7045.1997
PMCID: PMC179645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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