Article

A novel non-catalytic function of PA2803-encoded PcrP contributes to polymyxin B resistance in P. aeruginosa and redefines the functional role of the PA2803 subfamily.

2025-05-13

Abstract excerpt

The opportunistic human pathogen Pseudomonas aeruginosa (Pa), a leading cause of severe infections, becomes increasingly resistant to antibiotics, including the last resort antibiotic, polymyxin-B (PMB). Previous studies have shown that calcium (Ca 2+ ) at the levels encountered during infections increases Pa resistance to PMB. However, the mechanisms of this Ca 2+ regulation are not known. Here, we identified t...

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Literature Corpus work: 72b205cb-75d3-55b3-aeae-782e4e117a1c
DOI: 10.1101/2025.05.13.653872

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