Article
Closing the loop: the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003
Kato Akinori, Latifi Tammy, Groisman Eduardo A
Abstract excerpt
A fundamental question in biology is how an organism integrates multiple signals to mediate an appropriate cellular response. The PmrAPmrB two-component system of Salmonella enterica can be activated independently by Fe(3+), which is sensed by the PmrB protein, and in low Mg(2+), which is sensed by the PhoQ protein. The low-Mg(2+) activation requires pmrD, a PhoPPhoQ-activated gene that activates the response...
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