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CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae

1 Oct 2020

Abstract excerpt

Polymyxin resistance (PR) threatens the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. PR frequently arises through chemical modification of the lipid A portion of lipopolysaccharide. Various mutations are implicated in PR, including in three two-component systems-CrrA/B, PmrA/B, and PhoP/Q-and the negative regulator MgrB. Few have been functionally validated. Therefore, here we adapt...

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PMID: 33113377
DOI: 10.1016/j.celrep.2020.108313

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