Article
A small protein that mediates the activation of a two-component system by another two-component system.
The EMBO journal - 17 Apr 2000
Kox L F, Wösten M M, Groisman E A
Abstract excerpt
The PmrA-PmrB two-component system of Salmonella enterica controls resistance to the peptide antibiotic polymyxin B and to several antimicrobial proteins from human neutrophils. Transcription of PmrA-activated genes is induced by high iron, but can also be promoted by growth in low magnesium in a process that requires another two-component system, PhoP-PhoQ. Here, we define the genetic basis for the interaction...
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