Article
Expression of c-Kit and functional drug efflux are correlated in de novo acute myeloid leukaemia.
Leukemia - 1 Nov 1997
Sincock P M, Ashman L K
Abstract excerpt
P-glycoprotein (Pgp), the major mediator of multidrug resistance (MDR) has often been implicated as a poor prognostic indicator in acute myeloid leukaemia (AML). We have previously reported that high expression of the receptor tyrosine kinase c-Kit in AML is associated with poor prognosis. To det...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acute Disease
- Antimetabolites, Antineoplastic
- Cyclosporine
- Daunorubicin
- Drug Resistance, Multiple
- Fluorescent Antibody Technique, Indirect
- Humans
- Immunosuppressive Agents
- Leukemia, Myeloid
- Phenotype
- Proto-Oncogene Proteins c-kit
- Rhodamine 123
- Rhodamines
- Tumor Cells, Cultured