Article
Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 1995
Schuurhuis G J, Broxterman H J, Ossenkoppele G J, Baak J P, Eekman C A, Kuiper C M, Feller N, van Heijningen T H, Klumper E, Pieters R
Abstract excerpt
Overexpression of P-glycoprotein (Pgp) or MDR1 mRNA has been shown to be a negative prognostic factor for clinical outcome in acute myeloid leukemia (AML). However, resistance to chemotherapy also occurs in the absence of Pgp overexpression. Therefore, besides Pgp expression, we have assessed the...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Acute Disease
- Antineoplastic Combined Chemotherapy Protocols
- Biological Transport
- Cytarabine
- Daunorubicin
- Doxorubicin
- Drug Resistance, Multiple
- Etoposide
- Humans