Article
CDC42 is required for polarized growth in human pathogen Candida albicans.
Eukaryotic cell - 1 Feb 2002
Ushinsky Sophia C, Harcus Doreen, Ash Josee, Dignard Daniel, Marcil Anne, Morchhauser Joachim, Thomas David Y, Whiteway Malcolm, Leberer Ekkehard
Abstract excerpt
Cdc42p is a member of the RAS superfamily of GTPases and plays an essential role in polarized growth in many eukaryotic cells. We cloned the Candida albicans CaCDC42 by functional complementation in Saccharomyces cerevisiae and analyzed its function in C. albicans. A double deletion of CaCDC42 was made in a C. albicans strain containing CaCDC42 under the control of the PCK1 promoter. When expression of the...
Topics
- Base Sequence
- Candida albicans
- DNA Primers
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genotype
- Humans
- Promoter Regions, Genetic
- cdc42 GTP-Binding Protein