PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

doi:10.1093/emboj/17.22.6527

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Article

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

The EMBO journal - 16 Nov 1998

Abo A, Qu J, Cammarano M S, Dan C, Fritsch A, Baud V, Belisle B, Minden A

Abstract excerpt

The GTPases Rac and Cdc42Hs control diverse cellular functions. In addition to being mediators of intracellular signaling cascades, they have important roles in cell morphogenesis and mitogenesis. We have identified a novel PAK-related kinase, PAK4, as a new effector molecule for Cdc42Hs. PAK4 in...

Topics

Actins
Amino Acid Sequence
Base Sequence
Biopolymers
Calcium-Calmodulin-Dependent Protein Kinases
Cell Cycle Proteins
Cell Line
Cytoskeleton
DNA, Complementary
GTP-Binding Proteins
Golgi Apparatus
Guanosine Triphosphate
Humans
JNK Mitogen-Activated Protein Kinases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Jurkat Cells

Mitogen-Activated Protein Kinases

Molecular Sequence Data

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9822598
DOI: 10.1093/emboj/17.22.6527
PMCID: PMC1171000

Genes

PAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9822598-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.