Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42.

doi:10.1002/yea.320100405

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Article

Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42.

Yeast (Chichester, England) - 1 Apr 1994

Ziman M, Johnson D I

Abstract excerpt

Cdc24p and Cdc42p are involved in the control of cell polarity during the Saccharomyces cerevisiae cell cycle. Cdc42p is a member of the Ras superfamily of GTPases and Cdc24p displays limited amino-acid sequence similarity with the Dbl proto-oncoprotein, which acts to stimulate guanine-nucleotide exchange on human Cdc42p. We have performed several genetic experiments to test whether Cdc24p and Cdc42p interact...

Topics

Alleles
Base Sequence
Cell Cycle
Cell Cycle Proteins
Cell Polarity
Fungal Proteins
GTP-Binding Proteins
Genes, Fungal
Genes, Lethal
Guanine Nucleotide Exchange Factors
Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Molecular Sequence Data

Multigene Family

Phenotype

Proto-Oncogene Proteins

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 7941732
DOI: 10.1002/yea.320100405

Genes

CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7941732-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42.PMID 7941732Read ↗

Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity.Semantic proximity Read ↗

Functions and functional domains of the GTPase Cdc42p.Semantic proximity Read ↗

Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe.Semantic proximity Read ↗

Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant lethal cdc42G12V and dominant negative cdc42D118A mutations.Semantic proximity Read ↗

Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.Semantic proximity Read ↗

ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae.Semantic proximity Read ↗

The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation.Semantic proximity Read ↗

Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.Semantic proximity Read ↗

Different domains of the essential GTPase Cdc42p required for growth and development of Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of the Saccharomyces cerevisiae cdc42-1ts allele and new temperature-conditional-lethal cdc42 alleles.Semantic proximity Read ↗

Characterization of synthetic-lethal mutants reveals a role for the Saccharomyces cerevisiae guanine-nucleotide exchange factor Cdc24p in vacuole function and Na+ tolerance.Semantic proximity Read ↗

CDC42 is required for polarized growth in human pathogen Candida albicans.Semantic proximity Read ↗

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