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Article

Evidence for a selected humoral immune response encoded by VH4 family genes in the synovial membrane of a patient with rheumatoid arthritis (RA).

Clinical and experimental immunology - 1 Oct 1996

Voswinkel J, Trümper L, Carbon G, Hopf T, Pfreundschuh M, Gause A

Abstract excerpt

The analysis of rearranged antibody-encoding genes from B cell foci in rheumatoid synovial tissue has characterized these cells as highly mutated memory B cells with a high proportion of members of the VH4 family. In order to characterize further the VH4 response in one patient, B cell-rich areas from different sections of synovial membrane (SM) were identified by CD20 staining, isolated by microdissection and...

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Identifiers

PMID: 8870691
DOI: 10.1046/j.1365-2249.1996.d01-806.x
PMCID: PMC2200547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for a selected humoral immune response encoded by VH4 family genes in the synovial membrane of a patient with rheumatoid arthritis (RA).PMID 8870691Read ↗

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