Article
Evidence for a selected humoral immune response encoded by VH4 family genes in the synovial membrane of a patient with rheumatoid arthritis (RA).
Clinical and experimental immunology - 1 Oct 1996
Voswinkel J, Trümper L, Carbon G, Hopf T, Pfreundschuh M, Gause A
Abstract excerpt
The analysis of rearranged antibody-encoding genes from B cell foci in rheumatoid synovial tissue has characterized these cells as highly mutated memory B cells with a high proportion of members of the VH4 family. In order to characterize further the VH4 response in one patient, B cell-rich areas...
Topics
- Aged
- Arthritis, Rheumatoid
- B-Lymphocytes
- Base Sequence
- Female
- Gene Expression
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunoglobulins
- Knee Joint
- Molecular Sequence Data