Article
dic(5;17): a recurring abnormality in malignant myeloid disorders associated with mutations of TP53.
Genes, chromosomes & cancer - 1 Nov 1997
Wang P, Spielberger R T, Thangavelu M, Zhao N, Davis E M, Iannantuoni K, Larson R A, Le Beau M M
Abstract excerpt
We have identified three unbalanced translocations involving chromosomes 5 and 17, der(5)t(5;17), der(17)t(5;17), and dic(5;17), in the malignant cells from 17 patients with myeloid neoplasms. Six patients had a primary myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) de novo; ten patients had therapy-related MDS and/or AML (t-MDS/t-AML), and one patient had chronic myelogenous leukemia in myeloid...
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