Article
Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS.
Oncotarget - 22 Mar 2016
Kanagal-Shamanna Rashmi, Luthra Rajyalakshmi, Yin Cameron C, Patel Keyur P, Takahashi Koichi, Lu Xinyan, Lee John, Zhao Chong, Stingo Francesco, Zuo Zhuang, Routbort Mark J, Singh Rajesh R, Fox Patricia, Ravandi Farhad, Garcia-Manero Guillermo, Medeiros L Jeffrey, Bueso-Ramos Carlos E
Abstract excerpt
Isolated isochromosome 17q, i(17q), accounts for less than 1% of myeloid neoplasms that are commonly classified as myelodysplastic/myeloproliferative neoplasms, acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or myeloproliferative neoplasms (MPN). We have shown previously that these cases have distinctive clinicopathologic features, a poor prognosis and absence of TP53 mutations. However, their...
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