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Article

Myelodysplastic neoplasms with unbalanced whole-arm translocation der(5;19)(p10;q10): association with double-hit TP53 mutations.

International journal of hematology - 1 Feb 2026

Kojima Kensuke, Tsuge Noriko, Yoshida Shohei, Umebara Dai, Nishida Yoshie, Miyazaki Shiori, Asagiri Tadashi

Abstract excerpt

Unbalanced whole-arm translocation der(5;19)(p10;q10) is a rare but recurrent cytogenetic aberration noted in patients with myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). Eight cases of MDS/AML with der(5;19)(p10;q10) have been previously reported. Here, we describe three additional cases of MDS with der(5;19)(p10;q10) at our institution, in which we identified myeloid malignancy-associated...

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Source

Identifiers

PMID: 41004032
DOI: 10.1007/s12185-025-04076-z

Genes

TP53
CD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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