Article
A new genetic abnormality leading to TP53 gene deletion in chronic lymphocytic leukaemia.
British journal of haematology - 1 Mar 2012
López Cristina, Baumann Tycho, Costa Dolors, López-Guerra Mónica, Navarro Alba, Gómez Cándida, Arias Amparo, Muñoz Concha, Rozman María, Villamor Neus, Colomer Dolors, Montserrat Emili, Campo Elías, Carrió Ana
Abstract excerpt
The analysis of chromosomal abnormalities provides significant prognostic information in patients with chronic lymphocytic leukaemia (CLL), a disease with a highly heterogeneous clinical course. Chromosomal abnormalities commonly found are trisomy 12, del(13)(q14), del(11)(q22-23), del(17)(p13) and del(6)(q21). Translocations are present in some patients and affect regions recurrently involved in CLL. This report...
Topics
- Aged
- Aged, 80 and over
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 8
- DNA Mutational Analysis
- Female
- Gene Deletion
- Genes, Immunoglobulin Heavy Chain
- Genes, p53
- Humans
- In Situ Hybridization, Fluorescence
- Karyotype