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Suppression of transformed phenotype and tumorigenicity after transfer of chromosome 4 into U251 human glioma cells.

Genes, chromosomes & cancer - 1 Nov 1997

Pershouse M A, Ligon A H, Pereira-Smith O M, Killary A M, Yung W K, Steck P A

Abstract excerpt

The development of primary human brain tumors, particularly glioblastoma multiforme (GBM), has been associated with a number of molecular and chromosomal abnormalities. In this study, a novel tumor suppressor locus was identified and localized after the transfer of a human chromosome 4 into U251 human GBM cells. Hybrid clones containing a transferred neomycin-resistance tagged chromosome 4 revealed an inability...

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PMID: 9365833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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